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KMID : 0032220150270040371
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Annals of Dermatology
2015 Volume.27 No. 4 p.371 ~ p.375
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Efficacy and Safety of Calcipotriol/Betamethasone Dipropionate Ointment for the Treatment of Trachyonychia: An Open-Label Study
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Park Jung-Min
Cho Hyun-Ho
Kim Won-Jeong
Mun Je-Ho
Song Margaret
Kim Hoon-Soo
Ko Hyun-Chang
Kim Byung-Soo
Kim Moon-Bum
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Abstract
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Background: Despite efforts to treat trachyonychia, there is no promising treatment modality.
Objective: This study evaluated the efficacy and safety of calcipotriol plus betamethasone dipropionate ointment on trachyonychia.
Methods: A total of 39 patients with 432 nails affected by trachyonychia were enrolled. All patients applied calcipotriol/betamethasone ointment once daily without occlusion for 6 months. Outcome measures were assessed by physician’s global assessment (degree of roughness: 0, clear; 1, mild; 2, moderate; 3, marked; 4, severe) at all time points.
Results: After 6 months of therapy, 98.6% (426/432) of nails showed significant clinical improvement; 4.2% were completely free from nail lesions. The mean physician global assessment score decreased significantly from 3.5 to 1.7 points (p＜ 0.05). No serious side effects were reported, except mild pruritus and erythema in 2 patients.
Conclusion: This is the first study to prospectively evaluate the efficacy and safety of calcipotriol/betamethasone ointment for the treatment of trachyonychia. The results indicate topical calcipotriol/betamethasone is an effective and safe treatment for symptom improvement of trachyonychia. (Ann Dermatol 27(4) 371∼375, 2015)
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KEYWORD
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Calcipotriol/betamethasone, Nails, Psoriasis, Topical, Tra-chyonychia, Treatment
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